SAMe contributes to the balancing of the activity associated with brain neurotransmitters including Dopamine, Norepinephrine, Epinephrine, Seratonin and Phosphatidylserine. SAMe enhances the binding of neurotransmitters to receptor sites within the brain which in turn result in increased activity of Seratonin and Dopamine. By methylating certain phospholipids in the cell membranes, SAMe can enhance cell membrane fluidity.3-5 These factors improve the way brain cells communicate with each other.
The clinical evidence for the effectiveness of SAMe as a mood enhancing nutrient, has been well supported in nearly 100 published studies.6-12 Since the 1970s, SAMe has been found effective in reducing depressed moods in Schizophrenics and in most other types of depressed states.13-15 One area being the exception is perhaps Bipolar Depression (Manic-Depressive) where SAMe is not recommended. A review of the references at the end of the technical bulletin will give the details of the studies with SAMe in this area.
What is very exciting is that numerous clinical studies have shown that SAMe is effective, safe and fast acting as compared to many of the standard tricyclic anti-depressants without any of the negative side effects of these drugs.
A dietary supplement to support positive mood balance, liver, and joint function.
Each enteric coated tablet contains 400 mg of S-Adenosyl-methionine in the tosylate disulfate from which yields 200 mg of elemental SAM-e per tablet.
Other ingredients: cellulose, mannitol, hydroxypropylmethyl-cellulose, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica.
As a dietary supplement, take 1 tablet twice daily between meals.
Warning: Check with your doctor if you are taking MAO inhibitor drugs. Persons with Bipolar Disorder (manic depression) should not take SAM-e.